Description

2-Methyl-n-(Tetrahydro-2H-Pyran-4-Ylcarbonyl)-Alanine is a specialized non-proteinogenic amino acid derivative featuring a tetrahydro-2H-pyran-4-carbonyl protecting group. This compound is of significant value as a key chiral building block and intermediate in advanced organic synthesis, particularly for the development of pharmaceuticals and bioactive molecules. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex peptide mimetics and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of novel therapeutic agents, including protease inhibitors and enzyme modulators.
• Peptidomimetic Synthesis: Used to introduce constrained, non-natural amino acid residues into peptide chains to enhance metabolic stability and bioavailability.
• Medicinal Chemistry Research: Serves as a versatile building block in structure-activity relationship (SAR) studies and lead optimization processes.
• Agrochemical Development: Employed in the synthesis of advanced crop protection agents with specific chiral requirements.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects requiring high-purity, complex organic intermediates.

Basic Information

Product Name	2-Methyl-n-(Tetrahydro-2H-Pyran-4-Ylcarbonyl)-Alanine
CAS No.	1219979-74-4
Molecular Formula	C10H17NO4
Molecular Weight	215.25 g/mol
Synonyms	2-Methyl-N-(tetrahydro-2H-pyran-4-ylcarbonyl)alanine; (2S)-2-Methyl-3-oxo-3-(oxan-4-yl)propanoic acid; 2-Methylalanine tetrahydro-2H-pyran-4-carbonyl derivative; THP-Protected 2-Methylalanine; 4-(2-Methyl-2-carboxyethylcarbamoyl)tetrahydropyran; Alanine, N-(tetrahydro-2H-pyran-4-ylcarbonyl)-, 2-methyl-; 1219979-74-4
EINECS	Contact for details

Quality Control

Our 2-Methyl-n-(Tetrahydro-2H-Pyran-4-Ylcarbonyl)-Alanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.