Description

n-(3-Amino-4-Fluorophenyl)Tetrahydro-2H-Pyran-4-Carboxamide is a high-purity, advanced pharmaceutical intermediate characterized by its specific aromatic amine and carboxamide functional groups. This compound matters for its critical role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular architecture. Pharmaceutical R&D and manufacturing organizations need this material to develop and produce next-generation small molecule drugs, where its structural features enable targeted pharmacological activity.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel Active Pharmaceutical Ingredients (APIs) for various therapeutic classes.
• Oncology Drug Development: Used in research and production of targeted cancer therapies due to its fluorinated aniline moiety.
• Central Nervous System (CNS) Drug Synthesis: Serves as a building block for compounds targeting neurological disorders.
• Kinase Inhibitor Production: Integral to the manufacturing of specific kinase inhibitors, a major class of signaling pathway modulators.
• Chemical Biology & Proteomics: Employed in the design of molecular probes and tools for studying biological pathways.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global drug development pipelines.

Basic Information

Product Name	n-(3-Amino-4-Fluorophenyl)Tetrahydro-2H-Pyran-4-Carboxamide
CAS No.	1219949-45-7
Molecular Formula	C12H15FN2O2
Molecular Weight	238.26 g/mol
Synonyms	4-Fluoro-3-aminophenyl tetrahydro-2H-pyran-4-carboxamide; Tetrahydro-2H-pyran-4-carboxylic acid (3-amino-4-fluorophenyl)amide; 1219949-45-7; 4-Fluoro-m-phenylenediamine tetrahydro-2H-pyran-4-carboxamide; N-(3-Amino-4-fluorophenyl)oxane-4-carboxamide; Oxane-4-carboxamide, N-(3-amino-4-fluorophenyl)-; 3-Amino-4-fluoroaniline tetrahydro-2H-pyran-4-carboxamide
EINECS	Contact for details

Quality Control

Our n-(3-Amino-4-Fluorophenyl)Tetrahydro-2H-Pyran-4-Carboxamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediate use. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.