Description

1,2-Bis(tert-Butoxycarbonyl)Hexahydropyridazine-3-Carboxylic Acid is a specialized Boc-protected heterocyclic carboxylic acid building block of significant interest in advanced organic synthesis. Its primary value lies in serving as a key, high-purity intermediate for constructing complex nitrogen-containing molecular architectures. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active pharmaceutical ingredients (APIs) and fine chemicals where precise stereochemistry and functional group manipulation are required.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, especially those containing saturated diazine or piperazine-like motifs.
• Peptidomimetic Research: Used to introduce constrained, heterocyclic scaffolds into peptide backbones to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Serves as a building block for developing novel herbicides, fungicides, and insecticides with specific activity profiles.
• Ligand and Catalyst Development: Employed in the creation of novel chiral ligands and organocatalysts for asymmetric synthesis.
• Chemical Biology Probes: Utilized to synthesize labeled or tagged molecules for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A high-value starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Item	Details
Product Name	1,2-Bis(tert-Butoxycarbonyl)Hexahydropyridazine-3-Carboxylic Acid
CAS No.	1219380-72-9
Molecular Formula	C16H26N2O6
Molecular Weight	342.39 g/mol
Synonyms	1,2-Di-Boc-hexahydropyridazine-3-carboxylic acid; 3-Carboxy-1,2-bis(tert-butoxycarbonyl)hexahydropyridazine; Hexahydropyridazine-3-carboxylic acid, 1,2-bis[(1,1-dimethylethoxy)carbonyl]-; 1,2-Bis(Boc)hexahydropyridazine-3-carboxylic acid; 1,2-Bis(tert-butoxycarbonyl)perhydropyridazine-3-carboxylic acid; Boc-protected hexahydropyridazine carboxylic acid
EINECS	Contact for details

Quality Control

Our 1,2-Bis(tert-Butoxycarbonyl)Hexahydropyridazine-3-Carboxylic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, typically ≥95% (HPLC). Each lot undergoes rigorous analytical testing including HPLC for purity and assay, NMR (1H, 13C) for structural confirmation, and mass spectrometry. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP standards where applicable to support our clients' regulatory requirements in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.