Description

(4S)-(34Dichlorophenyl)-3,4-Dihydro-1-o-Triethylsilyl-1-Naphthol CAS NO 1217778-10-3 is a high-purity, chiral organosilicon intermediate of significant importance in advanced synthetic chemistry. Its value lies in its role as a key building block for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs). This compound is essential for research institutions and manufacturers in the pharmaceutical and fine chemical sectors who require precise stereochemical control and reliable synthetic pathways.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the multi-step synthesis of novel therapeutic agents and active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Utilized as a building block in catalytic asymmetric reactions to introduce specific stereocenters with high enantiomeric purity.
• Ligand and Catalyst Development: Serves as a foundational structure for developing novel chiral ligands and organocatalysts used in organic transformations.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals where the naphthol and silane functionalities are required.
• Material Science Research: Investigated for potential applications in creating advanced organic materials and polymers with specific optical or electronic properties.
• Process Chemistry & Scale-up: Used in route scouting and optimization for the commercial-scale production of complex molecules.

Basic Information

Product Name	(4S)-(34Dichlorophenyl)-3,4-Dihydro-1-o-Triethylsilyl-1-Naphthol
CAS No.	1217778-10-3
Molecular Formula	C27H32Cl2OSi
Molecular Weight	471.54 g/mol
Synonyms	(4S)-1-[(Triethylsilyl)oxy]-3,4-dihydro-4-(3,4-dichlorophenyl)-1(2H)-naphthalenone; (4S)-4-(3,4-Dichlorophenyl)-1-[(triethylsilyl)oxy]-3,4-dihydro-1H-naphthalen-2-one; (4S)-4-(3,4-Dichlorophenyl)-1-[(triethylsilyl)oxy]-3,4-dihydro-2(1H)-naphthalenone; (4S)-4-(3,4-Dichlorophenyl)-1-(triethylsilyloxy)-3,4-dihydro-1H-naphthalen-2-one; (4S)-4-(3,4-Dichlorophenyl)-1-(triethylsilyloxy)-3,4-dihydro-2(1H)-naphthalenone; (4S)-TES-Protected Dihydroxynaphthol Derivative; Chiral Triethylsilyl Naphthol Ether
EINECS	Contact for details

Quality Control

Our (4S)-(34Dichlorophenyl)-3,4-Dihydro-1-o-Triethylsilyl-1-Naphthol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) and standard purity assays, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and chiral purity are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.