Description

(R)-1-Boc-2-Propylpiperazine Hydrochloride is a high-purity chiral piperazine derivative, serving as a critical building block in modern pharmaceutical synthesis. Its primary value lies in enabling the development of enantiomerically pure active pharmaceutical ingredients (APIs), which is essential for ensuring drug efficacy and safety profiles. This advanced intermediate is specifically designed for use by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in areas requiring sophisticated chiral amine chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and antiviral therapies.
• Asymmetric Synthesis: Used as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions to induce stereoselectivity.
• API Development: Incorporated into the molecular scaffold of potential Active Pharmaceutical Ingredients (APIs) requiring the (R)-configured piperazine moiety.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization processes in drug discovery.
• Peptidomimetics: Serves as a constrained dipeptide mimic in the design of novel bioactive peptides with enhanced metabolic stability.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying biological targets and pathways.

Basic Information

Product Name	(R)-1-Boc-2-Propylpiperazine Hydrochloride
CAS No.	1217449-00-7
Molecular Formula	C12H25ClN2O2
Molecular Weight	264.79 g/mol
Synonyms	1-Piperazinecarboxylic acid, 2-propyl-, 1,1-dimethylethyl ester, (2R)-, hydrochloride; tert-Butyl (R)-2-propylpiperazine-1-carboxylate hydrochloride; (R)-1-(tert-Butoxycarbonyl)-2-propylpiperazine hydrochloride; (R)-N-Boc-2-propylpiperazine HCl; (R)-2-Propyl-1-Boc-piperazine hydrochloride; Boc-(R)-2-Propylpiperazine HCl; (R)-1-Boc-2-propylpiperazine HCl salt
EINECS	Contact for details

Quality Control

Our (R)-1-Boc-2-Propylpiperazine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A Certificate of Analysis (COA) detailing identity, purity (typically ≥98%), enantiomeric excess (ee), and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.