Description

n-[(1S,2S)-2-Amino-1,2-Diphenylethyl]-N'-[3,5-Bis(Trifluoromethyl)Phenyl]-Thiourea is a high-value chiral thiourea derivative, recognized for its role as a sophisticated organocatalyst and chiral ligand in asymmetric synthesis. Its molecular architecture, featuring a rigid 1,2-diphenylethylenediamine backbone and electron-deficient aryl group, makes it exceptionally effective for inducing high enantioselectivity in critical bond-forming reactions. This compound is essential for research and development chemists in the pharmaceutical and fine chemical industries who require precise stereochemical control to synthesize active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Asymmetric Organocatalysis: Employed as a powerful hydrogen-bond donor catalyst for enantioselective Michael additions, Mannich reactions, and acylations.
• Chiral Ligand in Metal Complexes: Used to form complexes with metals for asymmetric hydrogenation and other transition metal-catalyzed transformations.
• Pharmaceutical Intermediate: Serves as a key building block or chiral auxiliary in the multi-step synthesis of complex drug molecules.
• Methodology Development: A valuable tool for academic and industrial research groups developing new catalytic asymmetric methodologies.
• Fine Chemical Synthesis: Applied in the production of enantiomerically pure agrochemicals, flavors, and fragrances.
• Resolution Agent: Can be utilized for the chiral resolution of racemic mixtures due to its ability to form diastereomeric complexes.

Basic Information

Product Name	n-[(1S,2S)-2-Amino-1,2-Diphenylethyl]-N'-[3,5-Bis(Trifluoromethyl)Phenyl]-Thiourea
CAS No.	1217436-37-7
Molecular Formula	C23H19F6N3S
Molecular Weight	483.48 g/mol
Synonyms	(1S,2S)-N1-[3,5-Bis(trifluoromethyl)phenyl]-N2-(2-amino-1,2-diphenylethyl)thiourea; (S,S)-Thiourea, N-[(1,2-diphenyl-2-aminoethyl)]-N'-[3,5-bis(trifluoromethyl)phenyl]-; (1S,2S)-1,2-Diphenyl-2-{[3-(3,5-bis(trifluoromethyl)phenyl)thioureido]}ethylamine; Takemoto Catalyst Derivative; Chiral Thiourea Organocatalyst; (S,S)-DPEN-Thiourea Derivative; BTFMP-Thiourea Ligand
EINECS	Contact for details

Quality Control

Our production of n-[(1S,2S)-2-Amino-1,2-Diphenylethyl]-N'-[3,5-Bis(Trifluoromethyl)Phenyl]-Thiourea adheres to stringent quality protocols to ensure batch-to-batch consistency and high chiral purity, which is critical for catalytic performance. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and identity is provided with every shipment, supporting compliance in cGMP and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.