Description

10-Aminodecylmethanethiosulfonate, Hydrobromide is a specialized bifunctional chemical reagent featuring both a reactive thiosulfonate (MTS) group and a primary amine group separated by a ten-carbon alkyl linker. This unique structure makes it a critical tool for site-specific protein and peptide modification, enabling controlled cross-linking and labeling in complex biochemical systems. It is primarily utilized by researchers and developers in the fields of bioconjugation, proteomics, and pharmaceutical development to create stable, well-defined molecular constructs.

Application

• Site-Directed Protein Labeling: The methanethiosulfonate (MTS) group selectively reacts with cysteine thiols, allowing for precise attachment of fluorescent dyes, affinity tags, or other probes to engineered proteins.
• Cross-Linking Agent for Structural Biology: Used to study protein-protein interactions and map molecular structures by creating covalent bridges between specific amino acid residues.
• Antibody-Drug Conjugate (ADC) Linker Development: Serves as a heterobifunctional linker for connecting cytotoxic payloads to monoclonal antibodies via amine and thiol chemistries.
• Surface Functionalization: Immobilization of biomolecules onto solid supports (e.g., biosensor chips, nanoparticles) through amine-coupling chemistry after MTS-mediated surface activation.
• Peptide Synthesis and Modification: A building block for introducing a protected or reactive thiol handle into synthetic peptides via the amine terminus during SPPS (Solid-Phase Peptide Synthesis).
• Biomaterial Engineering: Cross-linking agent in the development of hydrogels and polymer scaffolds with tailored biological activity for tissue engineering.

Basic Information

Product Name	10-Aminodecylmethanethiosulfonate, Hydrobromide
CAS No.	1216881-94-5
Molecular Formula	C11H24BrNO2S2
Molecular Weight	346.35 g/mol
Synonyms	10-Amino-1-decyl methanethiosulfonate hydrobromide; 1-Aminodecane-10-methanethiosulfonate HBr; (10-Aminodecyl) methanethiosulfonate hydrobromide; MTS-amine linker C10; Amino-PEG10-MTS (HBr salt); Heterobifunctional MTS-NH2 linker; 10-(Methanethiosulfonyl)decylammonium bromide; Aminodecyl MTS reagent
EINECS	Contact for details

Quality Control

Our 10-Aminodecylmethanethiosulfonate, Hydrobromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for life science research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.