Description

GLPG 0492 is a highly selective, investigational small-molecule inhibitor targeting the G protein-coupled receptor GPR84, currently under evaluation for inflammatory and fibrotic disease applications. It matters for pharmaceutical R&D teams requiring high-purity, well-characterized tool compounds to support target validation, preclinical pharmacology, and lead optimization studies. Researchers in biopharmaceutical development, contract research organizations (CROs), and academic translational labs rely on GLPG 0492 CAS NO 1215085-92-9 for mechanistic studies in immunomodulation and metabolic inflammation models.

Application

• Preclinical target engagement and pharmacodynamic studies in rodent models of pulmonary fibrosis and non-alcoholic steatohepatitis (NASH)
• In vitro functional assays measuring inhibition of GPR84-mediated ERK phosphorylation and calcium mobilization in human immune cells
• Lead compound benchmarking in structure–activity relationship (SAR) campaigns for next-generation GPR84 antagonists
• Reference standard in bioanalytical method development (LC-MS/MS) for quantification in plasma and tissue homogenates
• Tool compound for investigating GPR84’s role in macrophage polarization and neutrophil chemotaxis
• Support of IND-enabling toxicology and safety pharmacology packages under GLP conditions

Basic Information

Product Name	GLPG 0492
CAS No.	1215085-92-9
Molecular Formula	C₂₄H₂₅F₃N₆O₂
Molecular Weight	486.49 g/mol
Synonyms	GLPG0492; GLPG-0492; N-(3-(3-(Trifluoromethyl)phenyl)-1H-pyrazol-5-yl)-2-(4-(methylsulfonyl)phenyl)acetamide; GPR84 inhibitor GLPG0492; 1215085-92-9; (R)-N-(3-(3-(Trifluoromethyl)phenyl)-1H-pyrazol-5-yl)-2-(4-(methylsulfonyl)phenyl)acetamide; IUPAC: N-[3-[3-(trifluoromethyl)phenyl]-1H-pyrazol-5-yl]-2-[4-(methylsulfonyl)phenyl]acetamide
EINECS	Not listed

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. Each batch is verified for identity (IR, HPLC retention time), assay (≥98.5% by HPLC), related substances (total impurities ≤1.5%), residual solvents (ICH Q3C compliant), and heavy metals (≤10 ppm). Testing adheres to USP & EP monograph guidelines where applicable, and manufacturing follows cGMP principles.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8°C under inert atmosphere (argon or nitrogen) to prevent degradation. Due to its hygroscopic nature, maintain in a low-humidity environment (<30% RH) and minimize exposure to ambient air during handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.5% – 101.0%
Related Substances	Single impurity ≤0.5%; Total impurities ≤1.5%
Residual Solvents (DMF, Acetone, Methanol)	Complies with ICH Q3C Class 2 limits
Water (KF)	≤0.5%
Heavy Metals	≤10 ppm
Sulfated Ash	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.