Description

(R)-7,8-Difluorochroman-4-Amine is a high-purity chiral amine building block of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and other therapeutic areas. It is essential for medicinal chemists and process development scientists in pharmaceutical and biotechnology companies who require enantiomerically pure intermediates for drug discovery and scale-up.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel drug candidates, especially in CNS and psychiatric disorder research.
• Asymmetric Synthesis: Used as a chiral auxiliary or precursor in catalytic asymmetric reactions to introduce stereochemical complexity.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Serves as a starting material for developing scalable, GMP-compliant synthetic routes to target APIs.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological targets and pathways.
• Agrochemical Research: Potential intermediate for developing novel, enantiomerically pure crop protection agents.

Basic Information

Product Name	(R)-7,8-Difluorochroman-4-Amine
CAS No.	1213550-52-7
Molecular Formula	C9H9F2NO
Molecular Weight	185.17 g/mol
Synonyms	(R)-7,8-Difluoro-3,4-dihydro-2H-1-benzopyran-4-amine; (4R)-7,8-Difluoro-3,4-dihydro-2H-chromen-4-amine; (R)-7,8-Difluoro-4-aminochroman; (R)-4-Amino-7,8-difluorochroman; 7,8-Difluorochroman-4-amine, (R)-; (R)-7,8-Difluoro-1,2,3,4-tetrahydro-4-aminonaphthalene (obsolete); (R)-4-Amino-7,8-difluoro-3,4-dihydro-2H-1-benzopyran
EINECS	Contact for details

Quality Control

Our (R)-7,8-Difluorochroman-4-Amine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, NMR for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after initial opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.