Description

(R)-5-Methylchroman-4-Amine is a chiral amine derivative of chroman, serving as a valuable building block in advanced organic synthesis. This compound matters for its role as a key chiral intermediate in the development of active pharmaceutical ingredients (APIs) and other fine chemicals, where stereochemical purity is critical. It is primarily needed by pharmaceutical R&D departments, agrochemical manufacturers, and specialty chemical companies focused on creating enantiomerically pure products.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the research and development of novel therapeutic agents, particularly in central nervous system (CNS) and cardiovascular drug candidates.
• Agrochemical Synthesis: Used in the production of enantiomerically pure pesticides and herbicides, where the specific (R)-enantiomer can offer enhanced biological activity.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands used in asymmetric catalysis, enabling more efficient and selective chemical transformations.
• Fine Chemical Production: Employed in the synthesis of complex, high-value specialty chemicals for electronics, materials science, and fragrance industries.
• Academic and Industrial Research: A standard reagent in medicinal chemistry and organic synthesis laboratories for method development and compound library generation.

Basic Information

Product Name	(R)-5-Methylchroman-4-Amine
CAS No.	1213506-92-3
Molecular Formula	C10H13NO
Molecular Weight	163.22 g/mol
Synonyms	(4R)-5-Methyl-3,4-dihydro-2H-1-benzopyran-4-amine; (R)-5-Methyl-3,4-dihydro-2H-chromen-4-amine; (R)-5-Methylchroman-4-ylamine; (R)-4-Amino-5-methylchroman; 5-Methylchroman-4-amine, (R)-; (R)-5-Methyl-4-chromanamine
EINECS	Contact for details

Quality Control

Our (R)-5-Methylchroman-4-Amine is produced under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, NMR, and mass spectrometry for structural confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.