Description

(S)-7,8-Difluorochroman-4-Amine is a high-value chiral amine building block characterized by its difluorinated chroman scaffold. This compound matters for its role as a critical intermediate in the synthesis of advanced pharmaceutical agents, particularly in the development of central nervous system (CNS) and cardiovascular drugs. Pharmaceutical research and development organizations, as well as fine chemical manufacturers, need this high-purity intermediate to enable efficient and stereoselective synthetic routes.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs).
• CNS Drug Discovery: Used in the synthesis of potential therapeutics targeting neurological and psychiatric disorders.
• Cardiovascular Agent Synthesis: Serves as a building block for compounds under investigation for heart-related conditions.
• Asymmetric Synthesis: Utilized in chiral pool synthesis and the preparation of enantiomerically pure compounds due to its defined (S)-configuration.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization programs.
• Preclinical Development: Supplied for the synthesis of compounds required for pharmacological and toxicological evaluation.

Basic Information

Product Name	(S)-7,8-Difluorochroman-4-Amine
CAS No.	1213161-36-4
Molecular Formula	C9H9F2NO
Molecular Weight	185.17 g/mol
Synonyms	(4S)-7,8-Difluoro-3,4-dihydro-2H-1-benzopyran-4-amine; (S)-7,8-Difluoro-3,4-dihydro-2H-chromen-4-amine; 7,8-Difluorochroman-4-amine, (S)-; 4-Chromanamine, 7,8-difluoro-, (4S)-; (S)-7,8-Difluorochroman-4-ylamine; (S)-4-Amino-7,8-difluorochromane
EINECS	Contact for details

Quality Control

Our (S)-7,8-Difluorochroman-4-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment and opened under dry, inert conditions to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.