Description

Methyl (4R)-4-Aminochromane-7-Carboxylate is a high-purity chiral building block of significant importance in modern pharmaceutical synthesis. This compound serves as a critical intermediate for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring stereochemical precision. It is primarily needed by research institutions, pharmaceutical development companies, and fine chemical manufacturers engaged in the creation of advanced drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug molecules, especially those targeting central nervous system (CNS) disorders and cardiovascular diseases.
• API Development: Used in research and development for constructing the core scaffold of new chemical entities (NCEs) with potential therapeutic activity.
• Asymmetric Synthesis: Employed in catalytic and stoichiometric asymmetric reactions due to its defined (4R) stereochemistry, enabling the production of enantiomerically pure compounds.
• Medicinal Chemistry Research: Serves as a versatile building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry: Utilized in the scale-up and optimization of synthetic routes for cost-effective and robust manufacturing of target molecules.

Basic Information

Product Name	Methyl (4R)-4-Aminochromane-7-Carboxylate
CAS No.	1212925-53-5
Molecular Formula	C11H13NO3
Molecular Weight	207.23 g/mol
Synonyms	(4R)-4-Amino-3,4-dihydro-2H-chromene-7-carboxylic acid methyl ester; Methyl (R)-4-amino-3,4-dihydro-2H-1-benzopyran-7-carboxylate; (R)-Methyl 4-amino-3,4-dihydro-2H-chromene-7-carboxylate; 7-Methoxycarbonyl-(4R)-4-aminochromane; 1212925-53-5; (4R)-4-Aminochroman-7-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl (4R)-4-Aminochromane-7-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent oxidation and moisture uptake. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.