Description

4-Sulfonic Acid-D-Phenylalanine is a specialized, high-purity sulfonated derivative of the D-isomer of the essential amino acid phenylalanine. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, particularly valued for introducing sulfonic acid functionality with precise stereochemical control. It is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries developing novel active pharmaceutical ingredients (APIs), peptide mimetics, and specialty surfactants.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of novel therapeutics, including enzyme inhibitors and receptor antagonists.
• Peptide Chemistry: Used in the synthesis of modified peptides and peptidomimetics to enhance solubility, stability, or biological activity.
• Asymmetric Synthesis: Employed as a chiral auxiliary or resolving agent in stereoselective synthesis to produce enantiomerically pure compounds.
• Bioconjugation & Labeling: Acts as a linker or functional handle for attaching molecules in bioconjugation chemistry and probe development.
• Surfactant & Detergent Research: Serves as a precursor for synthesizing specialized anionic surfactants with specific stereochemistry.
• Chemical Reference Standard: Used as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	4-Sulfonic Acid-D-Phenylalanine
CAS No.	1212221-09-4
Molecular Formula	C9H11NO5S
Molecular Weight	245.25 g/mol
Synonyms	D-4-Sulfophenylalanine; (R)-2-Amino-3-(4-sulfophenyl)propanoic acid; D-Phenylalanine-4-sulfonic acid; 4-Sulfo-D-phenylalanine; D-Phe(4-SO3H); (R)-3-(4-Sulfophenyl)alanine; 4-Sulfonato-D-phenylalanine
EINECS	Contact for details

Quality Control

Our 4-Sulfonic Acid-D-Phenylalanine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for research and cGMP manufacturing applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its strong acid/organic solvent nature, keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.