Description

5-(Trifluoromethyl)Pyridazine-3-Carboxylic Acid is a high-value trifluoromethylated heterocyclic building block essential for modern synthetic chemistry. This compound is critical for introducing the metabolically stable trifluoromethyl group and the versatile carboxylic acid functionality into target molecules, enabling the fine-tuning of physicochemical properties. It is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients, including kinase inhibitors and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in the development of kinase inhibitors, antiviral agents, and central nervous system (CNS) active compounds.
• Agrochemical Research: Used in creating advanced active ingredients for crop protection, leveraging the trifluoromethyl group to enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a building block for functionalized ligands, metal-organic frameworks (MOFs), and advanced polymers with tailored properties.
• Chemical Biology Probe Development: Employed in the design and synthesis of molecular probes and tags for studying biological systems and mechanisms of action.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis services catering to R&D and pilot-scale production needs.

Basic Information

Product Name	5-(Trifluoromethyl)Pyridazine-3-Carboxylic Acid
CAS No.	1211535-95-3
Molecular Formula	C6H3F3N2O2
Molecular Weight	192.10 g/mol
Synonyms	3-Pyridazinecarboxylic acid, 5-(trifluoromethyl)-; 5-(Trifluoromethyl)-3-pyridazinecarboxylic acid; 5-Trifluoromethylpyridazine-3-carboxylic acid; 1211535-95-3; 5-Trifluoromethyl-3-pyridazinecarboxylic acid
EINECS	Contact for details

Quality Control

We supply 5-(Trifluoromethyl)Pyridazine-3-Carboxylic Acid with a standard purity of ≥95% (by HPLC), with higher grades available upon request. Every batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. Our quality management system ensures traceability and compliance with cGMP principles for advanced intermediates, providing the consistency and documentation required for regulatory filings and seamless scale-up.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.