Description

n-(3-Ethynyloxetan-3-Yl)-2-Methylpropane-2-Sulfinamide is a specialized chiral sulfinamide building block featuring a reactive ethynyloxetane moiety. This compound is of significant value in modern pharmaceutical and agrochemical research as a key intermediate for the synthesis of complex, three-dimensional molecular architectures. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical industry for constructing novel drug candidates, particularly those targeting challenging biological pathways.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of active pharmaceutical ingredients (APIs) and preclinical drug candidates.
• Medicinal Chemistry: Used in fragment-based drug discovery and lead optimization to introduce constrained, sp3-rich frameworks into molecules.
• Agrochemical Synthesis: Serves as an advanced intermediate in the development of new pesticides and herbicides with enhanced efficacy.
• Chemical Biology: Employed in the synthesis of molecular probes and tool compounds for studying enzyme function and biological pathways.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or reagent in stereoselective transformations to control the formation of new stereocenters.
• Material Science Research: Investigated as a monomer or cross-linker precursor for novel polymers with specific thermal or mechanical properties.

Basic Information

Product Name	n-(3-Ethynyloxetan-3-Yl)-2-Methylpropane-2-Sulfinamide
CAS No.	1211284-34-2
Molecular Formula	C9H15NO2S
Molecular Weight	201.29 g/mol
Synonyms	2-Methyl-N-(3-oxetan-3-ylethynyl)propane-2-sulfinamide; tert-Butanesulfinamide, N-(3-ethynyl-3-oxetanyl)-; (R)- or (S)-N-(3-Ethynyloxetan-3-yl)-2-methylpropane-2-sulfinamide (enantiomers); 3-[(1,1-Dimethylethyl)sulfinyl]amino-3-oxetanylethyne; Oxetane-3-ethynyl tert-butylsulfinamide; Chiral Ethynyloxetane Sulfinamide; tert-Butylsulfinyl Oxetane Alkyne.
EINECS	Contact for details

Quality Control

Our n-(3-Ethynyloxetan-3-Yl)-2-Methylpropane-2-Sulfinamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data (HPLC/GC) are provided for every shipment, confirming identity, purity, and enantiomeric excess where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e. (for enantiomerically pure grade)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.