Description

6-Chloro-4-((trimethylsilyl)ethynyl)pyridazin-3-amine is a high-purity, advanced pharmaceutical intermediate featuring a unique pyridazine core functionalized with a chloro group and a trimethylsilyl-protected acetylene moiety. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel drug candidates targeting a range of therapeutic areas. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate complex heterocyclic structures into their molecular libraries.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small molecule therapeutics.
• Medicinal Chemistry Building Block: Used in structure-activity relationship (SAR) studies and hit-to-lead optimization campaigns due to its reactive handles for further functionalization.
• Agrochemical Research: Serves as a precursor in the development of novel herbicides, fungicides, and insecticides that leverage the pyridazine scaffold.
• Material Science Precursor: Potential use in the synthesis of organic electronic materials and ligands for catalysis, utilizing its conjugated system.
• Chemical Biology Probe Development: Employed in the creation of tool compounds and molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	6-Chloro-4-((trimethylsilyl)ethynyl)pyridazin-3-amine
CAS No.	1207625-15-7
Molecular Formula	C9H14ClN3Si
Molecular Weight	227.77 g/mol
Synonyms	3-Amino-6-chloro-4-[(trimethylsilyl)ethynyl]pyridazine; 6-Chloro-4-(2-trimethylsilylethynyl)pyridazin-3-amine; 6-Chloro-4-((trimethylsilyl)ethynyl)-3-pyridazinamine; 4-((Trimethylsilyl)ethynyl)-6-chloropyridazin-3-amine; 1207625-15-7; TMS-protected ethynyl pyridazine amine; Chloro-TMS-ethynyl-pyridazinamine
EINECS	Contact for details

Quality Control

Our 6-Chloro-4-((trimethylsilyl)ethynyl)pyridazin-3-amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring the material meets the stringent requirements for pharmaceutical R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.