Description

3-Ethynyl-3-Hydroxy-1-Methylpyrrolidin-2-One is a high-purity, specialized pyrrolidinone derivative featuring both a reactive ethynyl group and a hydroxyl functionality on the same carbon atom. This unique bifunctional structure makes it a valuable advanced pharmaceutical intermediate and a versatile building block for organic synthesis. It is primarily utilized by research and development teams in the pharmaceutical, agrochemical, and fine chemical industries for the creation of novel active compounds and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for neurological and metabolic disorders.
• Organic Synthesis Building Block: Used in click chemistry (e.g., copper-catalyzed azide-alkyne cycloaddition) and other coupling reactions to construct complex heterocyclic compounds.
• Agrochemical Research: Serves as a precursor in the synthesis of novel herbicides, fungicides, and plant growth regulators.
• Material Science: Potential monomer or cross-linking agent for developing specialty polymers with tailored properties.
• Chemical Biology Probe Development: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological development and discovery chemistry projects.

Basic Information

Product Name	3-Ethynyl-3-Hydroxy-1-Methylpyrrolidin-2-One
CAS No.	1202769-93-4
Molecular Formula	C7H9NO2
Molecular Weight	139.15 g/mol
Synonyms	3-Ethynyl-3-hydroxy-1-methyl-2-pyrrolidinone; 1-Methyl-3-ethynyl-3-hydroxy-2-pyrrolidinone; 3-Hydroxy-3-ethynyl-1-methylpyrrolidin-2-one; 3-Ethynyl-3-hydroxy-N-methyl-2-pyrrolidone; 1-Methyl-3-ethynyl-3-hydroxypyrrolidin-2-one
EINECS	Contact for details

Quality Control

Our production of 3-Ethynyl-3-Hydroxy-1-Methylpyrrolidin-2-One adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high chemical purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes. We support cGMP-compliant manufacturing for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in its original packaging to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.