Description

4-Oxo-1-(Tetrahydro-2H-Pyran-4-Yl)-Cyclohexanecarbonitrile is a high-purity, advanced pharmaceutical intermediate characterized by its unique bicyclic nitrile-ketone structure. This compound is of significant commercial value for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs) and other fine chemicals. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing novel therapeutic agents and high-value products.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Research: Serves as a versatile scaffold for developing new active ingredients in crop protection and pest management formulations.
• Chemical Synthesis Building Block: Utilized in organic synthesis for constructing complex molecular architectures due to its reactive ketone and nitrile functional groups.
• Material Science Research: Investigated as a monomer or precursor for developing novel polymers and advanced materials with specific functional properties.
• Academic & R&D Laboratories: Employed in medicinal chemistry research for structure-activity relationship (SAR) studies and novel compound library generation.

Basic Information

Item	Details
Product Name	4-Oxo-1-(Tetrahydro-2H-Pyran-4-Yl)-Cyclohexanecarbonitrile
CAS No.	1202462-46-1
Molecular Formula	C₁₂H₁₇NO₂
Molecular Weight	207.27 g/mol
Synonyms	1-(Oxan-4-yl)-4-oxocyclohexane-1-carbonitrile; 4-Oxo-1-(tetrahydro-2H-pyran-4-yl)cyclohexanecarbonitrile; 1-(Tetrahydro-2H-pyran-4-yl)-4-oxocyclohexanecarbonitrile; 4-Oxo-1-tetrahydropyran-4-yl-cyclohexanecarbonitrile; THP-Cyclohexanone Nitrile Derivative; CAS 1202462-46-1
EINECS	Contact for details

Quality Control

Our production of 4-Oxo-1-(Tetrahydro-2H-Pyran-4-Yl)-Cyclohexanecarbonitrile adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Every lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to confirm identity, potency, and impurity profiles. We provide a detailed Certificate of Analysis (COA) with each shipment, and our quality systems are designed to support cGMP and ISO standards for pharmaceutical-grade intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed in a dry environment to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.