Description

Potassium 2-Chloro-3-Pyridyltrifluoroborate is a high-value organoboron reagent, specifically a potassium trifluoroborate salt, essential for modern synthetic chemistry. Its primary value lies in its enhanced stability and handling properties compared to traditional boronic acids, making it a superior coupling partner in Suzuki-Miyaura cross-coupling reactions. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for constructing pyridine-containing active pharmaceutical ingredients (APIs) and drug candidates via palladium-catalyzed cross-coupling.
• Agrochemical Development: Used in the synthesis of novel herbicides, fungicides, and insecticides that incorporate the 2-chloro-3-pyridyl moiety for enhanced biological activity.
• Material Science Research: Serves as a precursor for creating functionalized organic materials, liquid crystals, and ligands for catalysis.
• Suzuki-Miyaura Cross-Coupling Reactions: Its stability allows for more robust reaction conditions, longer shelf-life of reagents, and simplified purification processes in C-C bond formation.
• Chemical Library Production: Enables high-throughput parallel synthesis for medicinal chemistry and discovery programs seeking diverse compound libraries.
• Process Chemistry & Scale-up: Preferred in kilo-lab and pilot plant operations due to its non-hygroscopic nature (as the potassium salt) and reliable performance under manufacturing conditions.

Basic Information

Product Name	Potassium 2-Chloro-3-Pyridyltrifluoroborate
CAS No.	1201899-19-5
Molecular Formula	C5H3BClF3KN
Molecular Weight	213.44 g/mol
Synonyms	2-Chloro-3-pyridyltrifluoroborate potassium salt; Potassium (2-chloropyridin-3-yl)trifluoroborate; 2-Chloro-3-pyridinyltrifluoroboronic acid potassium salt; (2-Chloro-3-pyridyl)trifluoroboronate potassium; 3-Pyridylboronic acid, 2-chloro-, potassium trifluoroborate derivative; 2-Chloro-3-pyridineboronic acid, trifluoroborate potassium complex; K-2-Cl-3-PyBF3
EINECS	Contact for details

Quality Control

Our Potassium 2-Chloro-3-Pyridyltrifluoroborate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (1H, 11B, 19F), HPLC for purity, and elemental analysis, to ensure it meets the high standards required for sensitive cross-coupling chemistry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) in a controlled environment to maintain stability and prevent hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
11B NMR Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.