Description

18-Deoxyherboxidiene is a synthetic derivative of the natural product herboxidiene, a potent inhibitor of pre-mRNA splicing. This compound is a valuable research-grade chemical tool used to study the molecular mechanisms of RNA splicing and its role in cellular processes. It is primarily utilized by researchers in the fields of molecular biology, oncology, and drug discovery. The availability of high-purity 18-Deoxyherboxidiene is critical for ensuring reproducible and reliable experimental results in both academic and industrial R&D settings.

Application

• Biochemical Research: As a specific chemical probe to investigate the spliceosome machinery and pre-mRNA splicing pathways in vitro and in cell-based assays.
• Oncology Research: Used to study the role of aberrant RNA splicing in cancer development and to evaluate potential therapeutic targets.
• Drug Discovery: Serves as a reference compound or a lead structure for the development of novel anti-cancer agents targeting the splicing process.
• Mechanistic Studies: Employed to dissect the biological functions of specific genes and proteins involved in the splicing cascade.
• High-Throughput Screening (HTS): Utilized as a control or tool compound in screening campaigns to identify new splicing modulators.

Basic Information

Product Name	18-Deoxyherboxidiene
CAS No.	1200128-66-0
Molecular Formula	C34H52O8
Molecular Weight	588.78 g/mol
Synonyms	18-Deoxy-herboxidiene; GEX1A; (3S,4S,5R,6R,8S,9S,10R,11S,12S,14E,16E,18E,20R)-20-[(2S,3S)-3-[(2S,3S)-3,4-Dihydroxy-2-methylbutyl]oxiran-2-yl]-5,6,9,10,11,12-hexahydroxy-3,4,8,20-tetramethyl-11-prop-1-en-2-yl-16,18-docosadien-14-olide
EINECS	Contact for details

Quality Control

Our 18-Deoxyherboxidiene is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product at -20°C under an inert atmosphere. The material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Allow the vial to equilibrate to room temperature in a desiccator before opening to avoid condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.