Description

4-(Trifluoromethylthio)Phenyl Trifluoromethanesulfonate is a high-value, multi-functional chemical intermediate characterized by its trifluoromethanesulfonate (triflate) ester group and electron-withdrawing trifluoromethylthio substituent. This compound is a powerful electrophilic reagent, enabling efficient C-O and C-C bond formation in advanced organic synthesis. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures, particularly in the synthesis of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block for introducing the 4-(trifluoromethylthio)phenyl moiety into drug candidates, enhancing lipophilicity and metabolic stability.
• Agrochemical Synthesis: Used in the manufacture of advanced pesticides and herbicides, where the trifluoromethylthio group is a critical pharmacophore for bioactivity.
• Cross-Coupling Reactions: Serves as an excellent substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) due to the high reactivity of the triflate leaving group.
• Material Science Research: Employed in the development of specialty polymers and liquid crystals that require fluorinated aromatic components for specific electronic or surface properties.
• Organic Synthesis Reagent: Facilitates Friedel-Crafts alkylation/acylation and nucleophilic aromatic substitution reactions under mild conditions.

Basic Information

Product Name	4-(Trifluoromethylthio)Phenyl Trifluoromethanesulfonate
CAS No.	1199773-43-7
Molecular Formula	C9H4F6O3S2
Molecular Weight	338.24 g/mol
Synonyms	4-(Trifluoromethylthio)phenyl triflate; [4-(Trifluoromethylsulfanyl)phenyl] trifluoromethanesulfonate; 4-(Trifluoromethylthio)phenyl trifluoromethanesulphonate; 4-(Trifluoromethylmercapto)phenyl triflate; 1-[(Trifluoromethyl)sulfanyl]-4-[(trifluoromethyl)sulfonyloxy]benzene; p-(Trifluoromethylthio)phenyl triflate; Trifluoromethanesulfonic acid 4-[(trifluoromethyl)thio]phenyl ester
EINECS	Contact for details

Quality Control

Every batch of 4-(Trifluoromethylthio)Phenyl Trifluoromethanesulfonate is manufactured and analyzed under strict quality management systems. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards and customer specifications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its nature as a strong acid/organic solvent derivative, it should be kept away from incompatible materials such as strong bases and oxidizing agents. Use appropriate corrosion-resistant storage equipment.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.