Description

Trifluoromethyl Benzenesulfonate (5E) is a high-purity, advanced pharmaceutical intermediate and versatile building block in organic synthesis. Its core value lies in its role as a key reagent for introducing the trifluoromethylsulfonate (OTf) group, a powerful leaving group that facilitates a wide range of cross-coupling and functionalization reactions. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to develop novel fluorinated compounds with enhanced properties.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing fluorine for improved metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and environmental persistence.
• Cross-Coupling Reactions: Serves as an excellent electrophile in palladium-catalyzed reactions like Suzuki, Negishi, and Stille couplings for carbon-carbon bond formation.
• Polymer & Material Science: Employed in the synthesis of specialty monomers and fluorinated polymers for applications requiring specific chemical resistance or surface properties.
• Ligand & Catalyst Development: A precursor for synthesizing novel ligands and organometallic catalysts used in asymmetric synthesis and industrial catalysis.
• Fluorination Reagent: Acts as a source of the trifluoromethanesulfonyl (triflyl) group in nucleophilic substitution reactions.

Basic Information

Product Name	Trifluoromethyl Benzenesulfonate (5E)
CAS No.	1197209-25-8
Molecular Formula	C7H5F3O3S
Molecular Weight	226.17 g/mol
Synonyms	Benzenesulfonic acid, trifluoromethyl ester; (Trifluoromethyl) benzenesulfonate; Phenyl trifluoromethanesulfonate; Trifluoromethanesulfonic acid phenyl ester; Benzene, (trifluoromethylsulfonyloxy)-; Triflate benzene derivative; Phenyl triflate; 5E Trifluoromethyl Benzenesulfonate
EINECS	Contact for details

Quality Control

Our Trifluoromethyl Benzenesulfonate (5E) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.