Description

2-Propanesulfinamide, n-[1-(5-Bromo-2-Fluorophenyl)Ethylidene]-2-Methyl-, [S(R)]- is a high-purity, chiral sulfinamide building block of significant importance in modern synthetic chemistry. Its value lies in its role as a key chiral auxiliary or intermediate for the stereoselective synthesis of complex, biologically active molecules. This compound is primarily needed by pharmaceutical R&D and fine chemical synthesis teams focused on developing new active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: A critical chiral building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Asymmetric Synthesis: Utilized as a chiral sulfinylating agent or auxiliary to induce high enantioselectivity in C-N and C-C bond-forming reactions.
• Agrochemical Research: Serves as a precursor for the development of new, enantiomerically pure pesticides and herbicides.
• Ligand and Catalyst Development: Used in the preparation of chiral ligands for transition metal catalysis.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological development in organic and medicinal chemistry.
• Process Chemistry: Investigated for scale-up in the route design and optimization of commercial pharmaceutical processes.

Basic Information

Product Name	2-Propanesulfinamide, n-[1-(5-Bromo-2-Fluorophenyl)Ethylidene]-2-Methyl-, [S(R)]-
CAS No.	1194044-26-2
Molecular Formula	C₁₂H₁₅BrFNO₂S
Molecular Weight	332.22 g/mol
Synonyms	(S)-N-[(1E)-1-(5-Bromo-2-fluorophenyl)ethylidene]-2-methylpropane-2-sulfinamide; (S)-tert-Butanesulfinamide, N-[(1E)-1-(5-Bromo-2-fluorophenyl)ethylidene]-; (S)-N-(1-(5-Bromo-2-fluorophenyl)ethylidene)-2-methylpropane-2-sulfinamide; (S)-2-Methyl-N-[(1E)-1-(5-bromo-2-fluorophenyl)ethylidene]propane-2-sulfinamide; (S)-N-(1-(5-Bromo-2-fluorophenyl)ethylidene)-2-methyl-2-propanesulfinamide; (S)-tert-Butylsulfinyl Imine of 1-(5-Bromo-2-fluorophenyl)ethanone; Chiral Sulfinimine Intermediate
EINECS	Contact for details

Quality Control

Our 2-Propanesulfinamide, n-[1-(5-Bromo-2-Fluorophenyl)Ethylidene]-2-Methyl-, [S(R)]- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for chiral purity and assay, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.