Description

Propargyl-Peg4-N3 is a heterobifunctional polyethylene glycol (PEG) linker featuring a propargyl group and an azide (N3) group, enabling efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry. This compound is essential for creating stable, site-specific bioconjugates and constructing complex molecular architectures with precise control. It is primarily utilized by researchers and manufacturers in pharmaceutical development, bioconjugation, materials science, and diagnostic assay platforms.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Linker: For site-specific coupling of drugs, dyes, or proteins to biomolecules.
• Polymer and Dendrimer Synthesis: As a versatile building block for creating functionalized PEG-based polymers and branched structures.
• Surface Functionalization: For modifying nanoparticles, biosensors, and microarray slides with bioactive ligands.
• Chemical Biology Probes: In the development of activity-based probes and pull-down reagents for target identification.
• Diagnostic Reagent Formulation: Used in the preparation of stable, labeled detection reagents for immunoassays.
• Hydrogel and Biomaterial Crosslinking: To form biocompatible networks for drug delivery and tissue engineering scaffolds.

Basic Information

Product Name	Propargyl-Peg4-N3
CAS No.	1192590-91-2
Molecular Formula	C17H31N3O7
Molecular Weight	389.45 g/mol
Synonyms	Propargyl-PEG4-azide; Azido-PEG4-propargyl; 1-Azido-3,6,9,12-tetraoxapentadec-14-yn-15-ol; N3-PEG4-Alkyne; PEG4 alkyne-azide crosslinker; 14-Azido-3,6,9,12-tetraoxatetradec-1-yn-15-ol; Propargyl-PEG4-N3 linker; Heterobifunctional PEG linker, propargyl and azide
EINECS	Contact for details

Quality Control

Our Propargyl-Peg4-N3 is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to support your R&D and cGMP-compliant production needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.