Description

(7-Methoxy-Chroman-3-Yl)-Methylamine Hydrochloride CAS NO 1187932-66-6 is a high-purity, advanced pharmaceutical intermediate with a defined chiral center. This compound is critical for the synthesis of complex organic molecules, offering a versatile building block for medicinal chemistry research and development. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in creating novel therapeutic agents, particularly in the areas of central nervous system and cardiovascular drug discovery.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of potential drug candidates, especially for neurological and cardiovascular applications.
• Medicinal Chemistry Research: Serves as a crucial building block for constructing complex molecular libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Asymmetric Synthesis: Utilized in catalytic and stoichiometric asymmetric reactions to introduce the chroman scaffold with high enantiomeric purity.
• Reference Standard: Used as an analytical standard in method development and quality control for drug substance manufacturing.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial production scales.
• Academic Research: Used in university and institutional labs for studying heterocyclic chemistry, amine derivatives, and novel synthetic methodologies.

Basic Information

Product Name	(7-Methoxy-Chroman-3-Yl)-Methylamine Hydrochloride
CAS No.	1187932-66-6
Molecular Formula	C11H16ClNO2
Molecular Weight	229.70 g/mol
Synonyms	1-(7-Methoxy-3,4-dihydro-2H-chromen-3-yl)methanamine hydrochloride; 3-(Aminomethyl)-7-methoxy-3,4-dihydro-2H-1-benzopyran hydrochloride; 7-Methoxy-3-chromanmethylamine hydrochloride; (7-Methoxy-2,3-dihydro-4H-chromen-3-yl)methanamine hydrochloride; 3-(Aminomethyl)-7-methoxy-2,3-dihydro-4H-chromen-4-one hydrochloride (tautomer); 7-Methoxychroman-3-ylmethylamine HCl
EINECS	Contact for details

Quality Control

Our (7-Methoxy-Chroman-3-Yl)-Methylamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing identity, purity, impurity profile, and chiral excess data is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.