Description

4,10-Bis[(1-Oxido-2-Pyridinyl)Methyl]-1,4,7,10-Tetraazacyclododecane-1,7-Diacetic Acid is a sophisticated macrocyclic ligand belonging to the class of pyridine-N-oxide functionalized cyclen derivatives. This compound is highly valued for its exceptional chelating properties, forming stable complexes with a variety of metal ions, particularly lanthanides and transition metals. It is primarily utilized in advanced research and development for applications in medical imaging, catalysis, and materials science. The product is supplied with a CAS number of 1187176-56-2.

Application

• Contrast Agent Precursor: A key intermediate in the synthesis of high-relaxivity gadolinium(III)-based contrast agents for Magnetic Resonance Imaging (MRI).
• Radiopharmaceutical Chelator: Used to develop stable complexes with radioisotopes (e.g., 68Ga, 177Lu, 90Y) for targeted cancer diagnosis and therapy (theranostics).
• Catalysis Research: Serves as a ligand framework for designing homogeneous catalysts in organic synthesis and oxidation reactions.
• Luminescent Material Development: Employed in creating lanthanide complexes for applications in bio-sensing, OLEDs, and luminescent probes.
• Metal Ion Separation & Sensing: Utilized in analytical chemistry for selective extraction, separation, or fluorescent detection of specific metal ions.
• Chemical Biology Tool: Acts as a bifunctional chelator for labeling biomolecules (antibodies, peptides) with metal ions for diagnostic assays.

Basic Information

Item	Detail
Product Name	4,10-Bis[(1-Oxido-2-Pyridinyl)Methyl]-1,4,7,10-Tetraazacyclododecane-1,7-Diacetic Acid
CAS No.	1187176-56-2
Molecular Formula	C28H38N6O6
Molecular Weight	554.64 g/mol
Synonyms	Pyclen-DO2A; 1,7-Bis(carboxymethyl)-4,10-bis(2-pyridyl-N-oxide methyl)-1,4,7,10-tetraazacyclododecane; DO2A-pyNO2; B-278; H4DO2A-(pyNO)2; Pyridine N-oxide DO2A derivative; 4,10-Bis(2-pyridylmethyl N-oxide)-1,4,7,10-tetraaza-1,7-diacetic acid cyclododecane
EINECS	Contact for details

Quality Control

Our production of 4,10-Bis[(1-Oxido-2-Pyridinyl)Methyl]-1,4,7,10-Tetraazacyclododecane-1,7-Diacetic Acid adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and Mass Spectrometry. We ensure compliance with relevant standards for research and pharmaceutical intermediate applications. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.