Description

2-Bromo-1-(Bromomethyl)-3-Fluorobenzene is a specialized fluorinated and brominated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring both bromomethyl and bromo substituents on a fluorinated benzene ring, makes it a versatile precursor for constructing complex molecular architectures. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of fluorinated drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, where the fluorine and bromine atoms can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized phosphine or nitrogen-based ligands used in transition metal catalysis.
• Material Science Research: Employed in the synthesis of fluorinated organic semiconductors, liquid crystals, or polymers with tailored electronic properties.
• Cross-Coupling Reactions: The bromine atoms provide excellent handles for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl systems.
• Functional Group Transformation: The bromomethyl group can be further modified to aldehydes, carboxylic acids, or amines, expanding its utility in multi-step syntheses.

Basic Information

Product Name	2-Bromo-1-(Bromomethyl)-3-Fluorobenzene
CAS No.	1184918-22-6
Molecular Formula	C7H5Br2F
Molecular Weight	267.92 g/mol
Synonyms	1,2-Dibromo-3-fluoro-α-methylbenzene; 3-Fluoro-α,2-dibromotoluene; 2-Bromo-α-bromo-3-fluorotoluene; 3-Fluoro-1,2-bis(bromomethyl)benzene (isomer); 2-Bromo-1-(bromomethyl)-3-fluoro-benzene; Benzene, 2-bromo-1-(bromomethyl)-3-fluoro-; α,2-Dibromo-3-fluorotoluene
EINECS	Contact for details

Quality Control

Our 2-Bromo-1-(Bromomethyl)-3-Fluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.