Description

8-Chloro-6-Fluoro-3,4-Dihydro-2H-1-Benzopyran-4-Amine is a high-purity, advanced pharmaceutical intermediate characterized by its unique benzopyran scaffold. This compound matters for its critical role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex molecular architectures. Pharmaceutical R&D teams and fine chemical manufacturers need it to develop next-generation drugs, leveraging its specific halogenated pattern to modulate biological activity and pharmacokinetic properties.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Organic Synthesis Building Block: Serves as a versatile precursor for constructing complex heterocyclic compounds and fused ring systems.
• Agrochemical Development: Potential intermediate in the synthesis of novel crop protection agents and herbicides.
• Material Science Research: Investigated as a monomer or precursor for specialty polymers and advanced organic materials.

Basic Information

Product Name	8-Chloro-6-Fluoro-3,4-Dihydro-2H-1-Benzopyran-4-Amine
CAS No.	1184159-02-1
Molecular Formula	C9H9ClFNO
Molecular Weight	201.63 g/mol
Synonyms	4-Amino-8-chloro-6-fluoro-3,4-dihydro-2H-1-benzopyran; 8-Chloro-6-fluoro-3,4-dihydro-2H-chromen-4-amine; 8-Chloro-6-fluoro-3,4-dihydro-2H-1-benzopyran-4-amine; 4-Amino-8-chloro-6-fluoro-2H-chromene; 1184159-02-1; 8-Chloro-6-fluoro-2H-chromen-4-amine; 8-Chloro-6-fluoro-3,4-dihydro-2H-chromen-4-amine
EINECS	Contact for details

Quality Control

Our 8-Chloro-6-Fluoro-3,4-Dihydro-2H-1-Benzopyran-4-Amine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring the material meets the stringent requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.