Description

1-n-Cbz-Propane-1,2-Diamine-Hcl CAS NO 1179359-66-0 is a high-purity, protected diamine building block essential for advanced organic synthesis. This compound is a critical intermediate in the development of novel active pharmaceutical ingredients (APIs) and complex bioactive molecules. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in peptide chemistry, medicinal chemistry, and the synthesis of specialized chemical libraries.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates, particularly in oncology and neurology research.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to introduce a protected diamine functionality into peptide chains.
• Linker Chemistry: Serves as a versatile bifunctional linker for constructing antibody-drug conjugates (ADCs) and other targeted therapeutic agents.
• Medicinal Chemistry: Employed in the design and synthesis of focused compound libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Chemical Biology Probes: Utilized in the creation of molecular probes and labeled compounds for studying biological pathways and target engagement.
• Custom Synthesis: A foundational starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke fine chemicals.

Basic Information

Product Name	1-n-Cbz-Propane-1,2-Diamine-Hcl
CAS No.	1179359-66-0
Molecular Formula	C11H17ClN2O2
Molecular Weight	244.72 g/mol
Synonyms	1-N-Cbz-1,2-Diaminopropane Hydrochloride; (1R,2S)-1-[(Benzyloxy)carbonyl]-1,2-diaminopropane Hydrochloride; N-Cbz-1,2-Diaminopropane HCl; Nα-Cbz-1,2-Diaminopropane Hydrochloride; 1-[(Benzyloxy)carbonylamino]-2-aminopropane Hydrochloride; (1R,2S)-1-[(Benzyloxy)carbonylamino]-2-aminopropane Hydrochloride; Cbz-Dap-OH•HCl; Z-1,2-Diaminopropane Hydrochloride
EINECS	Contact for details

Quality Control

Our 1-n-Cbz-Propane-1,2-Diamine-Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, which include data from HPLC, NMR, and chiral purity analysis to meet the stringent requirements of pharmaceutical R&D and cGMP starting material guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.