Description

Spermine-[D8].4Hcl CAS NO 1173022-85-9 is a high-purity, deuterium-labeled internal standard of the essential polyamine spermine, specifically designed for advanced analytical applications. This isotopically labeled compound is critical for achieving precise and reliable quantification in mass spectrometry-based assays, eliminating matrix effects and ensuring data integrity. It is an indispensable tool for researchers and quality control laboratories in the pharmaceutical, biotechnology, and life science sectors, particularly for metabolomics studies, biomarker discovery, and pharmacokinetic research.

Application

• Quantitative Mass Spectrometry (LC-MS/MS, GC-MS): Serves as a stable isotope-labeled internal standard for the accurate quantification of endogenous spermine in complex biological matrices such as plasma, serum, urine, and tissue homogenates.
• Biomedical & Metabolomics Research: Enables precise tracking of polyamine metabolism dysregulation, which is implicated in studies of cancer, neurological disorders, and cellular proliferation.
• Pharmaceutical Development & PK/PD Studies: Used in pharmacokinetic (PK) and pharmacodynamic (PD) studies to monitor drug effects on polyamine pathways and to ensure accurate bioanalytical method validation.
• Diagnostic Assay Development: Essential for developing and calibrating high-sensitivity clinical diagnostic tests that measure polyamine levels as potential disease biomarkers.
• Quality Control & Reference Standard: Acts as a certified reference material (CRM) for calibrating analytical instruments and verifying the accuracy of in-house testing methods in QC laboratories.

Basic Information

Product Name	Spermine-[D8].4Hcl
CAS No.	1173022-85-9
Molecular Formula	C10H18D8N4•4HCl
Molecular Weight	348.18 g/mol (for free base C10H18D8N4)
Synonyms	N,N'-Bis(3-aminopropyl)-1,4-butanediamine-d8 tetrahydrochloride; Spermine-d8 tetrahydrochloride; Deuterated Spermine tetrahydrochloride; [2H8]-Spermine tetrahydrochloride; 1,5,10,14-Tetraazatetradecane-d8 tetrahydrochloride; Perdeuterated Spermine HCl; Internal Standard for Spermine (D8)
EINECS	Contact for details

Quality Control

Every batch of Spermine-[D8].4Hcl is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. Certificates of Analysis (COA) are provided, detailing critical parameters such as isotopic purity, chemical purity, and absence of interfering impurities. Our quality protocols are designed to meet the stringent requirements of research and regulated environments, ensuring traceability and consistency for your most sensitive applications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Keep container tightly sealed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D8)	≥ 98 atom % D
Water Content (KF)	≤ 2.0 %
Residue on Ignition	≤ 0.5 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.