Description

tert-Butyl [(2R,3S)-2-(2,5-Difluorophenyl)-5-hydroxytetrahydro-2H-pyran-3-yl]carbamate is a high-purity, chiral synthetic intermediate of significant importance in modern pharmaceutical development. Its value lies in its defined stereochemistry and functional groups, which make it a critical building block for constructing complex active pharmaceutical ingredients (APIs). This compound is primarily needed by research institutions and pharmaceutical companies engaged in the synthesis of novel therapeutic agents, particularly within medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders or infectious diseases.
• Medicinal Chemistry Research: Used in exploratory research for structure-activity relationship (SAR) studies and lead optimization due to its difluorophenyl and carbamate-protected amine functionalities.
• Process Chemistry & Scale-Up: Acts as a critical intermediate during the development and optimization of scalable, cost-effective synthetic routes for target molecules under Good Manufacturing Practice (GMP) guidelines.
• API Synthesis: Incorporated into the synthetic pathway of advanced, stereochemically complex Active Pharmaceutical Ingredients (APIs), ensuring the final product's desired biological activity.
• Asymmetric Synthesis Building Block: Utilized in reactions that require high enantiomeric and diastereomeric purity, leveraging its pre-defined (2R,3S) configuration.
• Reference Standard: Supplied as a high-purity compound for use as an analytical reference standard in quality control (QC) and research laboratories.

Basic Information

Product Name	tert-Butyl [(2R,3S)-2-(2,5-Difluorophenyl)-5-hydroxytetrahydro-2H-pyran-3-yl]carbamate
CAS No.	1172623-99-2
Molecular Formula	C16H21F2NO4
Molecular Weight	329.34 g/mol
Synonyms	Boc-DHFPH; (2R,3S)-3-[(tert-Butoxycarbonyl)amino]-2-(2,5-difluorophenyl)tetrahydro-2H-pyran-5-ol; tert-Butyl N-[(3S,4R)-4-(2,5-difluorophenyl)-6-hydroxyoxan-3-yl]carbamate; (2R,3S)-2-(2,5-Difluorophenyl)-5-hydroxytetrahydro-2H-pyran-3-yl carbamic acid tert-butyl ester; tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-hydroxytetrahydro-2H-pyran-3-yl)carbamate; 1172623-99-2; Boc-protected amino pyranol derivative
EINECS	Contact for details

Quality Control

Our tert-Butyl [(2R,3S)-2-(2,5-Difluorophenyl)-5-hydroxytetrahydro-2H-pyran-3-yl]carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) and diastereomeric purity, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.