Description

tert-Butyl [(2R,3S)-2-(2,5-Difluorophenyl)-3,4-Dihydro-2H-Pyran-3-Yl]Carbamate is a high-purity chiral building block and advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex, biologically active molecules, offering precise stereochemical control essential for modern drug development. It is primarily needed by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of novel therapeutic agents, particularly in the areas of antiviral and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs) and investigational new drugs.
• Antiviral Drug Development: Serves as a crucial precursor in the research and production of novel antiviral compounds.
• CNS-Active Compound Synthesis: Used in the construction of complex molecules targeting neurological disorders and CNS pathways.
• Asymmetric Synthesis: Employed in stereoselective reactions to introduce the (2R,3S) configuration into larger molecular frameworks.
• Process Chemistry & Scale-Up: Utilized in route scouting and optimization for the commercial-scale manufacturing of chiral drugs.
• Medicinal Chemistry Research: Provides a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.

Basic Information

Product Name	tert-Butyl [(2R,3S)-2-(2,5-Difluorophenyl)-3,4-Dihydro-2H-Pyran-3-Yl]Carbamate
CAS No.	1172623-98-1
Molecular Formula	C16H19F2NO3
Molecular Weight	311.33 g/mol
Synonyms	Boc-(2R,3S)-2-(2,5-Difluorophenyl)-3,4-dihydro-2H-pyran-3-amine; (2R,3S)-3-((tert-Butoxycarbonyl)amino)-2-(2,5-difluorophenyl)-3,4-dihydro-2H-pyran; tert-Butyl N-[(2R,3S)-2-(2,5-difluorophenyl)-3,4-dihydro-2H-pyran-3-yl]carbamate; (2R,3S)-2-(2,5-Difluorophenyl)-3,4-dihydro-2H-pyran-3-amine, N-Boc derivative; (2R,3S)-2-(2,5-Difluorophenyl)-3,4-dihydro-2H-pyran-3-yl carbamic acid tert-butyl ester; BOC-DHP(2,5-F2-Ph)-OH (stereospecific); A chiral dihydropyran carbamate intermediate
EINECS	Contact for details

Quality Control

Our tert-Butyl [(2R,3S)-2-(2,5-Difluorophenyl)-3,4-Dihydro-2H-Pyran-3-Yl]Carbamate is manufactured under strict quality management systems. The product undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) verification and NMR for structural confirmation, to ensure compliance with the high-purity standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and handled under conditions that minimize exposure to ambient light and humidity to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.