Description

2-Trifluoromethyl-Benzamidine Hydrochloride is a high-purity organic building block and pharmaceutical intermediate of significant commercial importance. Its core value lies in the trifluoromethyl group, which is a key structural motif for enhancing the metabolic stability, lipophilicity, and bioavailability of active pharmaceutical ingredients. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for synthesis and screening.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and protease inhibitor research.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides, where the trifluoromethyl group improves biological activity.
• Chemical Biology Research: Serves as a key precursor for creating chemical probes and tool compounds to study biological pathways.
• Material Science: Potential monomer or additive in the development of specialty polymers with unique surface properties.
• Organic Synthesis: The amidine hydrochloride group acts as a versatile handle for constructing heterocyclic compounds like imidazoles and pyrimidines.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations engaged in custom synthesis and process development for client projects.

Basic Information

Product Name	2-Trifluoromethyl-Benzamidine Hydrochloride
CAS No.	1171756-10-7
Molecular Formula	C8H8ClF3N2
Molecular Weight	224.61 g/mol
Synonyms	2-(Trifluoromethyl)benzamidine hydrochloride; Benzenecarboximidamide, 2-(trifluoromethyl)-, hydrochloride (1:1); α,α,α-Trifluoro-o-toluamidine hydrochloride; o-Trifluoromethylbenzamidine HCl; 2-(Trifluoromethyl)benzenecarboximidamide hydrochloride; 2-Carbamimidoylbenzotrifluoride hydrochloride; 2-Amidino-α,α,α-trifluorotoluene hydrochloride
EINECS	Contact for details

Quality Control

Our 2-Trifluoromethyl-Benzamidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, assay, and impurity profiles. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	97.0% - 102.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.