Description

2-Chloro-4-Fluoro-Benzamidine Hydrochloride is a high-purity benzamidine derivative, a critical building block in modern organic synthesis. Its primary value lies in its role as a key intermediate for the development of pharmaceutical compounds and bioactive molecules, particularly protease inhibitors. This compound is essential for research and development chemists and manufacturers in the pharmaceutical, agrochemical, and life science industries who require reliable, high-quality intermediates for complex synthesis.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, especially those targeting serine proteases.
• Protease Inhibitor Development: Serves as a core scaffold for creating potent and selective inhibitors for therapeutic applications.
• Agrochemical Research: Used in the development of new active ingredients for crop protection products.
• Biochemical Research: Employed in academic and industrial laboratories for studying enzyme mechanisms and protein interactions.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs engaged in bespoke chemical synthesis.
• Chemical Biology Probes: Utilized in the design of molecular probes to investigate biological pathways.

Basic Information

Product Name	2-Chloro-4-Fluoro-Benzamidine Hydrochloride
CAS No.	1171478-64-0
Molecular Formula	C7H7ClFN2•HCl
Molecular Weight	209.06 g/mol (Free base: 172.59)
Synonyms	2-Chloro-4-fluorobenzamidine hydrochloride; 2-Chloro-4-fluorobenzenecarboximidamide hydrochloride; 4-Fluoro-2-chlorobenzamidine HCl; Benzenecarboximidamide, 2-chloro-4-fluoro-, hydrochloride (1:1); (2-Chloro-4-fluorophenyl)methanimidamide hydrochloride
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Fluoro-Benzamidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.