Description

tert-Butyl 3-(4-(Benzyloxy)butyl)-5-(3,4,5-trifluorophenyl)-2H-1,4-oxazine-4(3H)-carboxylate is a high-value, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure incorporating a trifluorophenyl group. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular architecture. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities, especially for central nervous system (CNS) and anti-infective drug candidates.

Application

• Key Intermediate in Pharmaceutical Synthesis: Serves as a crucial building block for the research and development of new drug molecules.
• API Development for CNS Disorders: Used in the synthesis of potential therapeutics targeting neurological and psychiatric conditions.
• Precursor for Anti-infective Agents: Employed in the creation of novel compounds with potential antibacterial or antifungal properties.
• Medicinal Chemistry Research: A valuable tool for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry & Scale-Up: Used in developing and optimizing scalable synthetic routes for potential clinical trial materials.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations (CROs/CMOs) for custom synthesis projects.

Basic Information

Product Name	tert-Butyl 3-(4-(Benzyloxy)butyl)-5-(3,4,5-trifluorophenyl)-2H-1,4-oxazine-4(3H)-carboxylate
CAS No.	1166394-99-5
Molecular Formula	C26H31F3N2O4
Molecular Weight	492.53 g/mol
Synonyms	tert-Butyl 3-(4-(benzyloxy)butyl)-5-(3,4,5-trifluorophenyl)-3,4-dihydro-2H-1,4-oxazine-4-carboxylate; 4(3H)-Oxazine-4-carboxylic acid, 3-[4-(phenylmethoxy)butyl]-5-(3,4,5-trifluorophenyl)-2,3-dihydro-, 1,1-dimethylethyl ester; 1,4-Oxazine intermediate 1166394-99-5; BOC-protected oxazine derivative; 3-(4-(Benzyloxy)butyl)-5-(3,4,5-trifluorophenyl)-2H-1,4-oxazine-4(3H)-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (typically ≥95% to ≥98%), to ensure consistency and reliability for critical research and development applications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay, related substances, and residual solvents. We support compliance with ICH guidelines for impurities and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; the container should be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥95.0%
Related Substances (HPLC)	Total impurities ≤5.0%
Any single unknown impurity	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.