Description

1-(4-Chlorophenyl)-3-(1H-1,2,4-Triazol-3-Ylsulfanyl)-2-Propen-1-One is a high-purity, advanced pharmaceutical intermediate characterized by its unique chalcone-triazole hybrid structure. This compound is of significant commercial interest for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in antifungal and antimicrobial research. It is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop new therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel triazole-containing antifungal and antimicrobial agents.
• Agrochemical Research: Used as a building block for developing new crop protection agents with potential fungicidal activity.
• Chemical Biology & Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Fine Chemical Synthesis: Employed in the preparation of complex organic molecules for advanced material science and specialty chemical applications.
• Academic & Institutional Research: Utilized in universities and research institutes for investigating new heterocyclic compounds and their biological activities.

Basic Information

Product Name	1-(4-Chlorophenyl)-3-(1H-1,2,4-Triazol-3-Ylsulfanyl)-2-Propen-1-One
CAS No.	1164476-44-1
Molecular Formula	C11H8ClN3OS
Molecular Weight	265.72 g/mol
Synonyms	(2E)-1-(4-Chlorophenyl)-3-[(1H-1,2,4-triazol-3-yl)sulfanyl]prop-2-en-1-one; (E)-1-(4-Chlorophenyl)-3-((1H-1,2,4-triazol-3-yl)thio)prop-2-en-1-one; 3-[(1E)-3-(4-Chlorophenyl)-3-oxo-1-propen-1-yl]thio]-1H-1,2,4-triazole; 1-(4-Chlorophenyl)-3-(1H-1,2,4-triazol-3-ylthio)-2-propen-1-one; Chalcone-triazole sulfide derivative; 4-Chlorochalcone triazole thioether; CAS 1164476-44-1
EINECS	Contact for details

Quality Control

Our 1-(4-Chlorophenyl)-3-(1H-1,2,4-Triazol-3-Ylsulfanyl)-2-Propen-1-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability, consistency, and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be light-sensitive and should be handled under an inert atmosphere for long-term storage to maintain stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.