Description

2-(4-Methoxyphenyl)-6-(Trifluoromethyl)-4,5-Dihydropyridazin-3(2H)-One is a high-purity, advanced pharmaceutical intermediate characterized by its dihydropyridazinone core structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical industries for drug discovery and process development programs.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the research and synthesis of new chemical entities (NCEs) for drug discovery.
• Active Pharmaceutical Ingredient (API) Development: Used in the development and scale-up of potential APIs, especially those targeting central nervous system (CNS) or inflammatory pathways.
• Agrochemical Research: Employed as a building block for creating novel herbicides or pesticides, leveraging the biological activity of the pyridazinone moiety.
• Chemical Biology & Medicinal Chemistry: Utilized in structure-activity relationship (SAR) studies to optimize potency and selectivity of lead compounds.
• Process Chemistry & Scale-Up: Acts as a standardized intermediate for optimizing synthetic routes and manufacturing processes under cGMP conditions.
• Contract Research & Development (CRO/CDMO): Supplied to service organizations supporting pharmaceutical and biotech companies in their R&D pipelines.

Basic Information

Item	Details
Product Name	2-(4-Methoxyphenyl)-6-(Trifluoromethyl)-4,5-Dihydropyridazin-3(2H)-One
CAS No.	1161004-77-8
Molecular Formula	C12H11F3N2O2
Molecular Weight	272.22 g/mol
Synonyms	6-(Trifluoromethyl)-2-(4-methoxyphenyl)-4,5-dihydro-3(2H)-pyridazinone; 2-(4-Methoxyphenyl)-6-(trifluoromethyl)-4,5-dihydro-2H-pyridazin-3-one; 2-(p-Methoxyphenyl)-6-(trifluoromethyl)-4,5-dihydropyridazin-3(2H)-one; 1161004-77-8; 6-Trifluoromethyl-2-(4-methoxyphenyl)-4,5-dihydro-3(2H)-pyridazinone; 4,5-Dihydro-2-(4-methoxyphenyl)-6-(trifluoromethyl)-3(2H)-pyridazinone
EINECS	Contact for details

Quality Control

Our production of 2-(4-Methoxyphenyl)-6-(Trifluoromethyl)-4,5-Dihydropyridazin-3(2H)-One adheres to stringent quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications such as assay (HPLC), related substances, and residual solvents. Our quality commitment supports applications requiring material for research under GLP or development under cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is light-sensitive and should be handled and stored away from direct light exposure to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.