Description

3-(Tetrahydro-2H-Pyran-4-Yl)Indoline-5-Carboxylic Acid is a high-value, synthetically versatile indoline derivative that serves as a critical building block in modern pharmaceutical research and development. Its unique fused bicyclic structure, incorporating both indoline and tetrahydropyran motifs, makes it a privileged scaffold for constructing novel bioactive molecules. This compound is primarily sought after by medicinal chemists and process development scientists in the pharmaceutical and biotechnology sectors for the synthesis of potential drug candidates targeting a range of therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Scaffold: Used as a core structural element for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for advanced pharmaceutical intermediates during clinical development phases.
• Chemical Biology Probe Synthesis: Utilized to create tool compounds for investigating biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Serves as a starting material for custom synthesis projects within CDMO (Contract Development and Manufacturing Organization) facilities.

Basic Information

Product Name	3-(Tetrahydro-2H-Pyran-4-Yl)Indoline-5-Carboxylic Acid
CAS No.	1160248-21-4
Molecular Formula	C14H17NO3
Molecular Weight	247.29 g/mol
Synonyms	3-(Oxan-4-yl)-2,3-dihydro-1H-indole-5-carboxylic acid; 5-Carboxy-3-(tetrahydro-2H-pyran-4-yl)indoline; 1H-Indole-5-carboxylic acid, 2,3-dihydro-3-(tetrahydro-2H-pyran-4-yl)-; 3-(Tetrahydro-2H-pyran-4-yl)-2,3-dihydro-1H-indole-5-carboxylic acid; 3-(THP-4-yl)indoline-5-carboxylic acid; 1160248-21-4; 3-(Tetrahydropyran-4-yl)indoline-5-carboxylic acid
EINECS	Contact for details

Quality Control

Our 3-(Tetrahydro-2H-Pyran-4-Yl)Indoline-5-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via spectroscopic methods (NMR, IR, MS), to ensure it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). For long-term storage, consider holding under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.