Description

tert-Butyl (4-(Aminomethyl)Tetrahydro-2H-Pyran-4-Yl)Carbamate is a high-purity, protected amino alcohol derivative, serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a versatile scaffold for constructing complex molecules with precise stereochemistry and functional group compatibility. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs) and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates, especially in central nervous system (CNS) and antiviral research.
• Peptide Mimetics & PROTACs: Used to construct peptide backbones and as a linker component in Proteolysis Targeting Chimeras (PROTACs) due to its stable tetrahydropyran ring and protected amine.
• Agrochemical Synthesis: Serves as a precursor for novel herbicides and fungicides that require specific stereochemical configurations for optimal activity.
• Ligand & Catalyst Development: Employed in the preparation of chiral ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Custom Chemical Synthesis: Provides a versatile handle for medicinal chemistry and process R&D teams to explore new chemical spaces and optimize synthetic routes.

Basic Information

Product Name	tert-Butyl (4-(Aminomethyl)Tetrahydro-2H-Pyran-4-Yl)Carbamate
CAS No.	1158759-94-4
Molecular Formula	C12H23NO3
Molecular Weight	229.32 g/mol
Synonyms	4-[(tert-Butoxycarbonylamino)methyl]tetrahydro-2H-pyran-4-carboxylic acid; 4-(Aminomethyl)-N-Boc-tetrahydropyran-4-amine; 1,1-Dimethylethyl N-[[4-(aminomethyl)tetrahydro-2H-pyran-4-yl]]carbamate; Boc-4-Aminomethyl-THP-4-amine; tert-Butyl N-[(4-aminomethyl)oxan-4-yl]carbamate; 4-(Boc-amino)methyl-tetrahydropyran-4-ylamine; 1158759-94-4
EINECS	Contact for details

Quality Control

Our tert-Butyl (4-(Aminomethyl)Tetrahydro-2H-Pyran-4-Yl)Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every shipment upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.