Description

n-(5-Amino-2-Fluorophenyl)Tetrahydro-2H-Pyran-4-Carboxamide is a high-purity, advanced pharmaceutical intermediate characterized by its unique molecular scaffold combining a fluorinated aniline with a tetrahydropyran carboxamide moiety. This compound is of significant value for its role in the research and development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular modulation. It is primarily sought by pharmaceutical R&D teams and fine chemical manufacturers engaged in synthesizing complex, target-specific drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic research.
• Chemical Biology Probe Development: Used to create molecular tools for studying enzyme inhibition and receptor-ligand interactions due to its specific fluorinated aromatic structure.
• Agrochemical Research: Serves as a precursor in the development of new-generation pesticides and herbicides requiring fluorinated bioactive components.
• Material Science Applications: Potential use in the synthesis of specialty polymers and advanced organic electronic materials where fluorine substitution enhances stability and performance.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the life sciences industry.

Basic Information

Product Name	n-(5-Amino-2-Fluorophenyl)Tetrahydro-2H-Pyran-4-Carboxamide
CAS No.	1153258-09-3
Molecular Formula	C12H15FN2O2
Molecular Weight	238.26 g/mol
Synonyms	4-(5-Amino-2-fluorophenyl)carbamoyloxane; 5-Amino-2-fluoro-N-(tetrahydro-2H-pyran-4-yl)benzamide; Tetrahydro-2H-pyran-4-carboxylic acid (5-amino-2-fluorophenyl)amide; 1153258-09-3; 4-Pyrancarboxamide, N-(5-amino-2-fluorophenyl)tetrahydro-; N-(5-Amino-2-fluorophenyl)tetrahydro-2H-pyran-4-carboxamide
EINECS	Contact for details

Quality Control

Our production of n-(5-Amino-2-Fluorophenyl)Tetrahydro-2H-Pyran-4-Carboxamide adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for critical R&D and scale-up processes. All materials are subjected to comprehensive analytical characterization, including HPLC, NMR, and MS, to verify identity and purity. A Certificate of Analysis (COA) detailing all relevant specifications is provided with each shipment. Our quality systems are designed to support development under cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.