Description

1-(4-Chlorophenyl)-3-Hydroxycyclobutanecarboxylic Acid is a high-purity, synthetically versatile organic building block featuring a cyclobutane ring core. This compound matters as a critical chiral intermediate in modern pharmaceutical research and development, enabling the synthesis of complex, biologically active molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors for constructing novel chemical entities.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and anti-inflammatory drug candidates.
• Agrochemical Research: Used in the synthesis of novel herbicides and fungicides, leveraging the structural rigidity of the cyclobutane ring.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and organometallic chemistry.
• Material Science: Building block for advanced polymers and liquid crystals, where the chlorophenyl and carboxylic acid groups offer functionalization sites.
• Chemical Biology Probes: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies and probe molecule synthesis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects at various scales.

Basic Information

Product Name	1-(4-Chlorophenyl)-3-Hydroxycyclobutanecarboxylic Acid
CAS No.	1145681-01-1
Molecular Formula	C11H11ClO3
Molecular Weight	226.66 g/mol
Synonyms	3-Hydroxy-1-(4-chlorophenyl)cyclobutanecarboxylic Acid; 1-(p-Chlorophenyl)-3-hydroxycyclobutanecarboxylic Acid; (3-Hydroxy-1-(4-chlorophenyl)cyclobutyl)formic Acid; 1-(4-Chlorophenyl)-3-hydroxycyclobutane-1-carboxylic Acid; 1145681-01-1; 1-(4-Chlorophenyl)-3-hydroxy-1-cyclobutanecarboxylic Acid
EINECS	Contact for details

Quality Control

Our 1-(4-Chlorophenyl)-3-Hydroxycyclobutanecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity (if applicable), and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.