Description

(4R)-8-(Trifluoromethoxy)Chromane-4-Ylamine is a high-purity chiral amine building block of significant interest in advanced organic synthesis. Its value lies in its unique chromane scaffold and trifluoromethoxy substituent, which are critical for modulating the physicochemical and metabolic properties of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly where stereochemistry and fluorine incorporation are key design elements.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, especially in central nervous system (CNS) and cardiovascular therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the trifluoromethoxy group enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Investigated as a building block for specialty polymers and advanced organic materials with specific optical or electronic properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.

Basic Information

Product Name	(4R)-8-(Trifluoromethoxy)Chromane-4-Ylamine
CAS No.	1144502-12-4
Molecular Formula	C10H10F3NO2
Molecular Weight	233.19 g/mol
Synonyms	(4R)-8-(Trifluoromethoxy)-3,4-dihydro-2H-1-benzopyran-4-amine; (R)-8-(Trifluoromethoxy)chroman-4-amine; 4-Amino-8-(trifluoromethoxy)chroman, (4R)-; 1144502-12-4; (4R)-8-(Trifluoromethoxy)-3,4-dihydro-2H-chromen-4-amine; (R)-4-Amino-8-(trifluoromethoxy)chroman
EINECS	Contact for details

Quality Control

Our (4R)-8-(Trifluoromethoxy)Chromane-4-Ylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure compliance with high-purity standards for research and development use. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.