Description

n-(3-Chloro-4-Methoxyphenyl)-1-([1,2,4]Triazolo[4,3-B]Pyridazin-6-Yl)Piperidine-3-Carboxamide is a high-purity, advanced pharmaceutical intermediate designed for research and development. This compound is critical for medicinal chemists exploring novel therapeutic agents, particularly in the areas of kinase inhibition and central nervous system (CNS) disorders. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers requiring a reliable, high-quality building block for complex synthesis.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel active pharmaceutical ingredients (APIs) targeting specific disease pathways.
• Kinase Inhibitor Research: Core scaffold for the development and optimization of potent and selective kinase inhibitors for oncology and inflammatory diseases.
• CNS Drug Discovery: Used in research programs focused on neurological and psychiatric disorders due to its potential modulation of relevant biological targets.
• Medicinal Chemistry: Enables structure-activity relationship (SAR) studies and lead optimization campaigns in drug discovery.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for clinical trial materials.
• Academic Research: Utilized in university and institutional labs for biochemical and pharmacological studies.

Basic Information

Product Name	n-(3-Chloro-4-Methoxyphenyl)-1-([1,2,4]Triazolo[4,3-B]Pyridazin-6-Yl)Piperidine-3-Carboxamide
CAS No.	1144451-95-5
Molecular Formula	C19H18ClN7O2
Molecular Weight	411.85 g/mol
Synonyms	1-([1,2,4]Triazolo[4,3-b]pyridazin-6-yl)-N-(3-chloro-4-methoxyphenyl)piperidine-3-carboxamide; 1-(1,2,4-Triazolo[4,3-b]pyridazin-6-yl)-N-(3-chloro-4-methoxyphenyl)piperidine-3-carboxamide; 1144451-95-5; UNII-7J2J9V1L6T; 7J2J9V1L6T; CHEMBL3186478; BDBM50389341; AKOS025147324; ZINC000253902787
EINECS	Contact for details

Quality Control

Every batch of n-(3-Chloro-4-Methoxyphenyl)-1-([1,2,4]Triazolo[4,3-B]Pyridazin-6-Yl)Piperidine-3-Carboxamide is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for each lot, supporting compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere or with appropriate desiccant to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.