Description

1-[3-(Propan-2-Yl)[1,2,4]Triazolo[4,3-B]Pyridazin-6-Yl]-n-(1,3-Thiazol-2-Yl)Piperidine-3-Carboxamide is a high-purity, advanced pharmaceutical intermediate designed for research and development. This compound is critical for medicinal chemists exploring novel therapeutic agents, particularly in the areas of kinase inhibition and targeted oncology. It is essential for pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in the synthesis of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates targeting specific biological pathways.
• Kinase Inhibitor Research: Core scaffold for the development of potent and selective kinase inhibitors for oncology and inflammatory diseases.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies to optimize potency, selectivity, and pharmacokinetic properties.
• Preclinical Development: Serves as a critical material for producing batches required for in vitro and in vivo efficacy and safety studies.
• Chemical Biology Probes: Utilized to create tool compounds for investigating enzyme function and cellular signaling mechanisms.
• Custom Synthesis: Starting point for the custom manufacturing of specialized analogs for client-specific research programs.

Basic Information

Product Name	1-[3-(Propan-2-Yl)[1,2,4]Triazolo[4,3-B]Pyridazin-6-Yl]-n-(1,3-Thiazol-2-Yl)Piperidine-3-Carboxamide
CAS No.	1144434-11-6
Molecular Formula	C19H23N7OS
Molecular Weight	397.50 g/mol
Synonyms	1-[3-(Isopropyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]-N-(1,3-thiazol-2-yl)piperidine-3-carboxamide; 1-[3-(Propan-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]-N-(thiazol-2-yl)piperidine-3-carboxamide; 1-(3-Isopropyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-N-(1,3-thiazol-2-yl)piperidine-3-carboxamide; CAS 1144434-11-6; 1-[3-(Propan-2-yl)-1,2,4-triazolo[4,3-b]pyridazin-6-yl]-N-(1,3-thiazol-2-yl)piperidine-3-carboxamide
EINECS	Contact for details

Quality Control

Our 1-[3-(Propan-2-Yl)[1,2,4]Triazolo[4,3-B]Pyridazin-6-Yl]-n-(1,3-Thiazol-2-Yl)Piperidine-3-Carboxamide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept tightly sealed in a dry environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.