Description

2-(7,8-Dimethoxy-4-Methyl-2-Oxo-2H-Chromen-3-Yl)-n-[(2E)-5-Methyl-1,3,4-Thiadiazol-2(3H)-Ylidene]Acetamide CAS NO 1144433-49-7 is a high-purity, advanced pharmaceutical intermediate characterized by its unique hybrid molecular structure combining coumarin and thiadiazole moieties. This compound is of significant value for its role as a key building block in the research and development of novel therapeutic agents, particularly those targeting specific enzymatic pathways. It is primarily sought after by pharmaceutical R&D laboratories, biotechnology firms, and fine chemical manufacturers engaged in the synthesis of innovative drug candidates.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of novel active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and anti-inflammatory drug candidates.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies to explore and optimize the biological activity of new chemical entities derived from its core scaffold.
• Biochemical Probe Development: Employed in the design and synthesis of molecular probes for studying enzyme inhibition, receptor binding, and other cellular mechanisms.
• Academic & Institutional R&D: Utilized in university and research institute laboratories for fundamental studies in organic synthesis and drug discovery projects.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the pharmaceutical industry.

Basic Information

Product Name	2-(7,8-Dimethoxy-4-Methyl-2-Oxo-2H-Chromen-3-Yl)-n-[(2E)-5-Methyl-1,3,4-Thiadiazol-2(3H)-Ylidene]Acetamide
CAS No.	1144433-49-7
Molecular Formula	C18H17N3O5S
Molecular Weight	379.41 g/mol
Synonyms	N-[(2E)-5-Methyl-1,3,4-thiadiazol-2(3H)-ylidene]-2-(7,8-dimethoxy-4-methyl-2-oxo-2H-chromen-3-yl)acetamide; 2-(7,8-Dimethoxy-4-methyl-2-oxo-2H-chromen-3-yl)-N-[(2E)-5-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide; Coumarin-thiadiazole hybrid intermediate; 1144433-49-7; Acetamide, 2-(7,8-dimethoxy-4-methyl-2-oxo-2H-chromen-3-yl)-N-[(2E)-5-methyl-1,3,4-thiadiazol-2(3H)-ylidene]-
EINECS	Contact for details

Quality Control

Our 2-(7,8-Dimethoxy-4-Methyl-2-Oxo-2H-Chromen-3-Yl)-n-[(2E)-5-Methyl-1,3,4-Thiadiazol-2(3H)-Ylidene]Acetamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS), to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to meet specific client requirements or internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and handling properties. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.