Description

N,N'-(1S,2S)-1,2-Cyclohexanediyl Bis[N'-[3,5-Bis(Trifluoromethyl)Phenyl)]-Thiourea is a sophisticated chiral thiourea derivative, a class of compounds renowned for their utility as highly effective organocatalysts and anion-binding agents. Its value lies in the precise stereochemistry of the cyclohexanediamine backbone and the strong electron-withdrawing nature of the bis(trifluoromethyl)phenyl groups, which create a powerful hydrogen-bond donor motif. This compound is essential for researchers and manufacturers in asymmetric synthesis, pharmaceutical intermediate development, and advanced materials science, where it facilitates challenging enantioselective transformations.

Application

• Organocatalyst for Asymmetric Synthesis: Employed as a chiral hydrogen-bond donor catalyst in enantioselective reactions such as Michael additions, Mannich reactions, and acylations.
• Anion Recognition and Sensing: Used in the development of molecular sensors and receptors due to its strong affinity for binding anions like fluoride and acetate.
• Pharmaceutical Intermediate: Serves as a key chiral building block or catalyst in the synthesis of active pharmaceutical ingredients (APIs) requiring high enantiomeric purity.
• Ligand in Coordination Chemistry: Acts as a ligand for transition metals, potentially creating novel complexes for catalysis or material properties.
• Research & Development: A critical tool in academic and industrial R&D for exploring new methodologies in green chemistry and sustainable catalysis.
• Specialty Chemical Synthesis: Used in the preparation of other complex, value-added chiral compounds for the agrochemical and fine chemical industries.

Basic Information

Item	Detail
Product Name	N,N'-(1S,2S)-1,2-Cyclohexanediyl Bis[N'-[3,5-Bis(Trifluoromethyl)Phenyl)]-Thiourea
CAS No.	1140969-69-2
Molecular Formula	C24H20F12N4S2
Molecular Weight	656.56 g/mol
Synonyms	(1S,2S)-N,N'-Bis[3,5-bis(trifluoromethyl)phenyl]thiocarbamoyl-1,2-cyclohexanediamine; (1S,2S)-Cyclohexane-1,2-diyl bis(N-(3,5-bis(trifluoromethyl)phenyl)carbamothioate); (1S,2S)-1,2-Diaminocyclohexane N,N'-bis[3,5-bis(trifluoromethyl)phenyl]thiourea; Chiral Bis(thiourea) Catalyst; Jacobsen's Thiourea Derivative; Takemoto Catalyst Analog; Chiral Hydrogen-Bond Donor; Anion-Binding Receptor.
EINECS	Contact for details

Quality Control

Our production of this high-value chiral compound adheres to strict quality protocols to ensure batch-to-batch consistency and optimal catalytic performance. Every lot is characterized using advanced analytical techniques including HPLC, NMR, and chiral analysis to confirm chemical identity, high purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and efficacy.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.