Description

(1,3-Dioxolan-2-Ylmethyl)Zinc Bromide is a highly reactive organozinc reagent, specifically a Reformatsky-type reagent, used for the formation of carbon-carbon bonds. This compound matters for its ability to introduce the (1,3-dioxolan-2-yl)methyl group in a controlled manner, enabling the synthesis of complex organic molecules and valuable intermediates. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing β-hydroxy carbonyl derivatives and other functionalized structures.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for the preparation of β-lactams, statin side chains, and other bioactive molecules requiring precise stereochemistry.
• Agrochemical Active Ingredient Development: Used in the synthesis of complex herbicides, fungicides, and plant growth regulators.
• Fine Chemical and Specialty Material Production: Enables the construction of chiral ligands, complex ethers, and protected aldehyde equivalents for advanced material science.
• Academic and Industrial R&D: A critical tool in methodological development for new C-C bond-forming reactions and asymmetric synthesis.
• Synthesis of Natural Products and Fragrances: Employed in the stereoselective synthesis of complex natural product scaffolds and aroma chemicals.

Basic Information

Product Name	(1,3-Dioxolan-2-Ylmethyl)Zinc Bromide
CAS No.	1135389-59-1
Molecular Formula	C4H7BrO2Zn
Molecular Weight	232.39 g/mol
Synonyms	2-(Bromozinciomethyl)-1,3-dioxolane; (1,3-Dioxolan-2-ylmethyl)zinc bromide; Zinc, bromo[(1,3-dioxolan-2-yl)methyl]-; Reformatsky Reagent from 2-(Bromomethyl)-1,3-dioxolane; Bromo[(1,3-dioxolan-2-yl)methyl]zinc; (2-Bromo-1,3-dioxolan-2-yl)methylzinc bromide (tautomeric form)
EINECS	Contact for details

Quality Control

Our (1,3-Dioxolan-2-Ylmethyl)Zinc Bromide is manufactured under strict inert atmosphere conditions to ensure batch-to-batch consistency and reactivity. Each lot undergoes rigorous quality testing, including titration for active zinc content and analysis of key impurities by NMR and GC/HPLC. A comprehensive Certificate of Analysis (COA) detailing purity, concentration (typically supplied as a solution in THF or other solvents), and stability data is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. This material is moisture-sensitive (hygroscopic) and easily oxidized; it must be stored under an inert atmosphere (argon or nitrogen) at recommended temperatures between 2°C and 8°C for solutions. For extended stability, storage at lower temperatures (e.g., -20°C) may be advised. Keep away from strong acids, strong bases, and oxidizing agents. Use only in a well-ventilated fume hood.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Concentration	0.5 M in THF (or as specified)
Assay (Zn content)	≥ 95% (by titration)
Purity (NMR)	≥ 90%
Identification (IR/NMR)	Conforms to structure
Water Content (Karl Fischer)	< 500 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.