Description

3-Amino-Tetrahydropyrane-3-Carboxylic Acid CAS NO 1131623-12-5 is a specialized heterocyclic building block featuring both amino and carboxylic acid functional groups on the same carbon atom of a tetrahydropyran ring. This unique bifunctional structure makes it a valuable chiral synthon for constructing complex molecules in pharmaceutical research and development. It is primarily utilized by medicinal chemists and process R&D scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of novel active compounds and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of potential drug candidates, particularly in central nervous system (CNS) and antiviral research.
• Peptidomimetics & Bioisosteres: Used to incorporate constrained, ring-based amino acid analogs into peptide chains to improve metabolic stability and bioavailability.
• Ligand Synthesis: Serves as a precursor for chiral ligands and catalysts used in asymmetric synthesis.
• Agrochemical Research: Employed in the development of novel herbicides, fungicides, and insecticides with specific stereochemical requirements.
• Chemical Biology Probes: Useful for creating molecular probes to study enzyme function and biological pathways.
• Fine Chemical Synthesis: A versatile intermediate for the production of specialty chemicals and complex organic molecules.

Basic Information

Product Name	3-Amino-Tetrahydropyrane-3-Carboxylic Acid
CAS No.	1131623-12-5
Molecular Formula	C6H11NO3
Molecular Weight	145.16 g/mol
Synonyms	3-Aminooxane-3-carboxylic acid; 3-Aminotetrahydropyran-3-carboxylic acid; 3-Amino-3-carboxytetrahydropyran; 3-Amino-3-tetrahydropyrancarboxylic acid; (3R)-3-Aminooxane-3-carboxylic acid (for enantiomer); (3S)-3-Aminooxane-3-carboxylic acid (for enantiomer); 3-Amino-tetrahydropyran-3-carboxylic acid; THP-3-amino-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our 3-Amino-Tetrahydropyrane-3-Carboxylic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity (where applicable), and impurity profiles is provided with every shipment. We support development and commercial projects with specifications that can meet GMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (for enantiopure grade)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.