Description

(R)-3,3-Difluorocyclopentanamine Hydrochloride is a high-purity chiral amine building block essential for modern pharmaceutical and agrochemical research. Its value lies in the unique combination of a constrained cyclopentane scaffold and fluorine atoms, which are critical for modulating the biological activity, metabolic stability, and physicochemical properties of target molecules. This compound is primarily needed by medicinal chemists and process development scientists in the pharmaceutical industry for the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of central nervous system (CNS) drugs, enzyme inhibitors, and receptor modulators.
• Agrochemical Research: Used in the synthesis of advanced herbicides and pesticides, where the fluorine atoms enhance lipophilicity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands used in asymmetric synthesis and catalysis.
• Peptidomimetics & Bioisosteres: The difluorocyclopentylamine moiety is employed to replace peptide bonds or other functional groups to improve drug-like properties.
• Chemical Biology Probes: Utilized in the creation of molecular probes for studying enzyme function and biological pathways.
• Process Chemistry & Scale-up: Supplied for route scouting and optimization during the transition from laboratory to pilot and commercial-scale manufacturing.

Basic Information

Item	Details
Product Name	(R)-3,3-Difluorocyclopentanamine Hydrochloride
CAS No.	1117936-64-7
Molecular Formula	C5H10ClF2N
Molecular Weight	157.59 g/mol
Synonyms	(R)-3,3-Difluorocyclopentylamine hydrochloride; (1R)-3,3-Difluorocyclopentan-1-amine hydrochloride; (R)-3,3-Difluorocyclopentan-1-amine HCl; 3,3-Difluorocyclopentanamine hydrochloride, (R)-; (R)-3,3-Difluorocyclopentylamine HCl; (R)-Amino-3,3-difluorocyclopentane hydrochloride
EINECS	Contact for details

Quality Control

Every batch of (R)-3,3-Difluorocyclopentanamine Hydrochloride is produced under strict quality management systems. We employ advanced analytical techniques, including chiral HPLC, NMR, and LC-MS, to ensure high enantiomeric purity and chemical identity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.