Description

6-Chloro-3-(3-Fluorophenyl)[1,2,4]Triazolo[4,3-B]Pyridazine is a high-purity, advanced pharmaceutical intermediate featuring a fused triazolopyridazine heterocyclic core. This compound is of significant commercial interest for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) therapeutic areas. Research and development teams in the global pharmaceutical and biotechnology sectors require this precise chemical scaffold to drive innovation in drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potential drug candidates targeting specific biological pathways.
• Kinase Inhibitor Development: Serves as a core structural motif for designing and optimizing small-molecule kinase inhibitors, a major class of oncology therapeutics.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore new chemical entities with improved efficacy and safety profiles.
• Bioconjugation & Probe Synthesis: The reactive chloro and fluorophenyl groups allow for further functionalization, making it useful for creating biochemical probes and labeled compounds.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical companies in early-stage development and scale-up activities.

Basic Information

Product Name	6-Chloro-3-(3-Fluorophenyl)[1,2,4]Triazolo[4,3-B]Pyridazine
CAS No.	1094425-19-0
Molecular Formula	C12H6ClFN4
Molecular Weight	260.65 g/mol
Synonyms	6-Chloro-3-(3-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazine; 6-Chloro-3-(3-fluorophenyl)-s-triazolo[4,3-b]pyridazine; 6-Chloro-3-(3-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine; 6-Chloro-3-(3-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine; 1094425-19-0; 3-(3-Fluorophenyl)-6-chloro-[1,2,4]triazolo[4,3-b]pyridazine
EINECS	Contact for details

Quality Control

Every batch of 6-Chloro-3-(3-Fluorophenyl)[1,2,4]Triazolo[4,3-B]Pyridazine is manufactured under a strict quality management system and undergoes comprehensive analytical testing. We ensure compliance with the high-purity standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound should be kept under an inert atmosphere for long-term storage to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.